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Endocrinology, placed in the context of the latest literature, it can be surmised that metastin, appearing downstream of different neuroendocrine regulators, stimulates GnRH release from hypothalamic GnRH neurons, which in turn effects both LH and FSH secretion. Therefore, kisspeptins exert their results on both LH and FSH secretion by performing by means of the GnRH receptor, pointing once again to the hypothalamus as a pivotal site of action for this protein with respect to reproductive axis dynamics. In both rodents and nonhuman primates, the effects of kisspeptins on LH could be blocked by a GnRH antagonist, demonstrating that kisspeptins are acting by means of GnRH and its receptor to stimulate LH release (i.e.
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